A biofilm has been proposed to have a significant role in chronic infections in the horse. It has been suggested for over a decade that chronic uterine infections resistant to antimicrobials may be due to biofilm production. The involvement of a biofilm in cases of bacterial endometritis has not been clearly elucidated, but many reproductive specialists suspect a biofilm plays a significant role in infectious endometritis. In this article Dr. Ryan Ferris, a board certified theriogenologist from Colorado State University, explains the lifestyles of bacteria, how a biofilm is formed, how they protect bacteria and their implications on equine reproduction.